Serious games focus on goals beyond pure entertainment. The term has traditionally been associated with games intended for educational purposes, although the focus can be much broader. In our case, we are researching health games in different aspects that include their use for diagnosis, treatment, monitoring and training within the framework of health and well-being. One of the most productive lines is serious games for cognitive evaluation. We have gone deeper into how to develop multimodal interactive systems that achieve contrastable and sustained training of cognitive skills over time. To this end, several interactive systems are developed, mainly in the form of video games, which enhance skills such as attention, concentration, reflexes or memory and are validated with techniques based on neuroscience and on quantitative analysis of Electroencephalographic (EEG) signals.